Man United vs Burnley takes center stage at Old Trafford this weekend, as Ruben Amorim’s Red Devils search for their first Premier League victory of the season.

Following a shock EFL Cup elimination to Grimsby Town in midweek, the pressure is mounting on United to respond, but a growing list of injuries could shape the manager’s tactical approach.

Predicted XI for Man United vs Burnley

Based on the latest team news, Manchester United are expected to line up in a 3-4-3 formation, balancing defensive caution with attacking width.

With Lisandro Martínez ruled out due to a knee injury, Matthijs de Ligt should marshal the back line alongside Luke Shaw and promising youngster Yoro.

Predicted Manchester United XI:
Bayindir; Yoro, De Ligt, Shaw; Amad, Casemiro, Fernandes, Dorgu; Mbeumo, Šeško, Cunha.

For Burnley, Vincent Kompany’s side will look to frustrate their hosts with a compact structure.

Despite injury setbacks, they still possess energetic midfield options to challenge United’s rhythm.

Predicted Burnley XI:
Dubravka; Walker, Humphreys, Esteve, Ekdal, Hartman; Mejbri, Ugochukwu, Cullen, Anthony; Foster.

Key absentees and available players

The most significant blow to United remains Lisandro Martínez, whose long-term absence leaves Amorim without a natural leader in central defense.

Meanwhile, Noussair Mazraoui is doubtful with a thigh problem, creating further uncertainty at full-back.

On the positive side, Casemiro and Bruno Fernandes are fit and ready, providing United with vital midfield control.

Up front, Benjamin Šeško and Matheus Cunha are expected to spearhead the attack, supported by the creativity of Bryan Mbeumo.

Burnley, meanwhile, are without Zeki Amdouni (ACL), Manuel Benson (Achilles), and Jordan Beyer (knee).

Right-back Connor Roberts remains a doubt but could feature depending on his late fitness test.

Tactical approach: How United may play against Burnley

Amorim will likely demand a strong reaction from his squad after recent setbacks.

Expect United to control possession, using Casemiro to shield the defense while Fernandes pushes higher to unlock Burnley’s deep block.

Wide players like Amad and Dorgu will be crucial for stretching the game, while Šeško’s movement inside the box offers a direct goal threat.

Burnley’s plan will almost certainly revolve around compact defending and counter-attacks through quick runners in wide areas.

United must remain patient, avoid defensive lapses, and capitalize on early chances to ease pressure.

Ultimately, the Man United vs Burnley fixture is set up as a test of United’s resilience and tactical adaptability, with three points being non-negotiable if Amorim’s side want to steady their campaign.