As October 2025 approaches, the San Francisco 49ers prepare for a pivotal stretch in their season.
With several key matchups looming — including prime-time games and divisional clashes — the month offers both opportunities and tests.
Below is a full preview of the 49ers’ October slate, opponents, kickoff times, and what fans should watch for.
49ers October 2025 Fixtures and Results Preview
October will challenge the 49ers’ depth, their adaptability on the road, and their capacity to win under the lights.
Coming off their September results, San Francisco must balance roster health, especially at quarterback and skill positions, with strong execution.
One highlight: the 49ers will travel for a Thursday Night Football contest early in the month, a spotlight demand where every snap is magnified.
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Later in October, they face cross-conference matchups as well as a key late game in Houston.
The team’s ability to manage travel, recovery, and consistent performance will be under the microscope.
Historically, October has been a turning point for playoff hopefuls — momentum swings are frequent.
For the 49ers, October 2025 might define whether they compete for the NFC West crown, secure a wild card berth, or fall behind in the race.
San Francisco 49ers October 2025 Game Times and Opponents
Here are the opponents, dates, and kickoff times for the 49ers’ October matches, along with context about home/away status:
| Date | Opponent | Venue | Kickoff Time (ET) | Notes |
|---|---|---|---|---|
| Thu, Oct 2, 2025 | Los Angeles Rams | Away | 8:15 p.m. ET | Thursday Night Football road test |
| Sun, Oct 12, 2025 | Tampa Bay Buccaneers | Away | 1:00 p.m. ET | Cross-conference trip to Florida |
| Sun, Oct 26, 2025 | Houston Texans | Away | 1:00 p.m. ET | Late October road hurdle |
The 49ers’ October run is entirely on the road — no home games in that month. That means travel, time-zone shifts, and unfamiliar settings will play a large role in their performance curve.
San Francisco 49ers NFL Schedule: October 2025 Game List
- October 2 — at Los Angeles Rams, 8:15 p.m. ET
- October 12 — at Tampa Bay Buccaneers, 1:00 p.m. ET
- October 26 — at Houston Texans, 1:00 p.m. ET
Complete San Francisco 49ers NFL Schedule October 2025
In full, the 49ers’ October lineup demands resilience.
Here’s how the month stacks up:
- Week 5 (Thu, Oct 2): Travel to L.A. to face the Rams under Thursday Night lights
- Week 7 (Sun, Oct 12): Mid-month trip to Tampa Bay
- Week 8 (Sun, Oct 26): Road game in Houston
Read also: Pittsburgh Steelers NFL Schedule October 2025
All three are away games — no reprieve in October at Levi’s Stadium. For a team that prizes home-field advantage, this stretch is a grind.
