Man United injury concerns continue to trouble Ruben Amorim as he prepares his side for a crucial Premier League clash against newly-promoted Burnley at Old Trafford.

After a disappointing midweek exit from the EFL Cup, the Red Devils are under pressure to bounce back, but absences could heavily influence the manager’s tactical setup.

Man United injury list before facing Burnley

Manchester United head into the weekend with several fitness doubts.

The most notable long-term absentee is Lisandro Martínez, who remains sidelined with a serious knee injury and is expected to miss multiple months of the season.

His absence has left a void in central defense that has forced Amorim to rotate heavily in recent weeks.

Meanwhile, Noussair Mazraoui is rated doubtful after sustaining a thigh problem.

The Moroccan full-back has been undergoing late fitness tests, but medical staff remain cautious about rushing his return.

If he fails to recover, youngster Yoro or experienced cover could be drafted into the defensive line.

This limited defensive depth underlines just how damaging the current Man United injury list has become, especially with matches coming thick and fast.

Suspensions affecting Man United lineup

Unlike the injury situation, United currently have no confirmed suspensions for the Burnley clash.

This comes as a relief for Amorim, who has already had to navigate a threadbare squad in recent weeks.

However, several players, including Casemiro and Luke Shaw, are just one booking away from short-term bans, meaning discipline will be crucial in a physical derby-like match against Burnley.

For Burnley, the picture is more complicated: Zeki Amdouni (ACL), Manuel Benson (Achilles), and Jordan Beyer (knee) are confirmed absentees, while Connor Roberts faces a late fitness test after a knock.

How the Man United injury list impacts Amorim’s plans

The combination of injuries and tight scheduling means Amorim faces difficult choices in his starting XI.

Without Martínez, the defense lacks leadership and aerial dominance, placing added responsibility on Matthijs de Ligt and Luke Shaw.

If Mazraoui is not cleared to play, tactical adjustments may see Amad pushed into a more defensive role, or a system shift to a back three.

Going forward, Amorim will still rely on his attacking trio of Bruno Fernandes, Benjamin Šeško, and Matheus Cunha to provide creativity and goals.

However, the fragility of the defense and the uncertainty around fitness highlight just how disruptive the Man United injury situation has become this early in the season.

With Burnley fighting for survival and United desperate for a first league win, the depth of Amorim’s squad—and his ability to adapt—could prove decisive at Old Trafford on Saturday.